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Tryptophan supplements fell out of favor when a contaminated batch from Japan caused thousands to fall ill in the 1980s.

Unfortunately, this supplement’s usefulness for depression may be more hype than substance.

Several other brain-related disorders besides depression are related to low serotonin, including autism, ADHD, bipolar disorder, sleep disorders, and schizophrenia (3).

Many people with depression or other serotonin deficiency symptoms and conditions are searching for better ways to increase serotonin levels naturally without the use of drugs.

It’s particularly helpful for Parkinson’s and schizophrenia patients who also have depression (14).